A Case of Dermatosis Neglecta Caused by an Inappropriate Habit of Applying a Moisturizer

Vol. 29, No. 5, 2017 657 Received September 9, 2016, Accepted for publication October 10, 2016 Corresponding author: Soyun Cho, Department of Dermatology, SMG-SNU Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea. Tel: 82-2-870-2381, Fax: 82-2-870-3866, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology disease (HHD), respectively. SERCA2 and SPCA1 regulate the Ca levels of the endoplasmic reticulum and Golgi apparatus. Translation, translocation, folding, and processing of adhesional molecule of keratinocyte are closely related with Ca levels; mutations affecting the Ca pumps induce histologically acantholysis and dyskeratosis. An earlier study revealed that SERCA2 and SPCA1 staining was less intense than normal in both DD and HHD skin, but SERCA2 was more affected in DD patients and SPCA1 in those with HHD. We found that the SERCA2 staining intensity was similar in both tissues, but SPCA1 expression level was much reduced in IFAD compared to normal tissue. Thus, IFAD seems to be more closely associated with low-level SPCA1 expression. In summary, to the best of our knowledge, our present IFAD case is the first to be associated with DLE. Although further work is required, our study showed that SPCA1 expression was reduced in IFAD tissue; SPCA1 may thus play a role in disease pathogenesis.